Both print 12 mm labels from built-in QWERTY keyboards without an app. Brother adds 30 saved labels, more templates, and a broader TZe tape range; DYMO keeps the workflow compact with direct formatting keys and D1 tape.
Choose the Brother PT-D220 for reusable formats, 30 saved labels, narrower 3.5 mm tape, and the broader range of TZe materials. Choose the DYMO LabelManager 160 for short, occasional labels when a compact body and direct formatting keys matter more than a design library. Both require separate power and brand-specific replacement cassettes.
Keenrove EDITORIAL · 4 min read · Checked 2026-10-03
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A label maker earns its drawer space only if making the next label feels easier than reaching for a marker. Brother's P-touch PT-D220 and DYMO's LabelManager 160 both remove the phone from that decision: each has a QWERTY keyboard, a preview screen, physical formatting controls, and support for labels up to 12 mm wide. They are direct substitutes for pantry bins, file folders, cables, craft drawers, and shared office supplies.
The important split is not app versus no app. Neither selected model needs an app for its normal workflow. Brother builds a deeper library around repeated designs, while DYMO concentrates on a compact device with quick font-size, bold, italic, box, underline, and vertical controls. The cartridge system you choose also becomes a long-term commitment because Brother TZe and DYMO D1 cassettes are not interchangeable.
Choose the tape system before comparing the keyboards
The PT-D220 accepts Brother TZe tape in 3.5, 6, 9, and 12 mm widths. Brother describes its standard laminated TZe tape as resistant to water, fading, and chemicals, and the machine also supports specialized TZe families such as extra-strength adhesive, flexible ID, tamper-evident, and iron-on fabric. That range is useful when the same label maker must cover slim cable flags, ordinary folder tabs, and storage containers.
The LabelManager 160 uses DYMO D1 cassettes in 6, 9, and 12 mm widths. DYMO's manual allows two text lines on 9 or 12 mm tape but only one line on 6 mm tape. D1 comes in multiple colors, and DYMO offers standard and durable families, but this exact machine does not accept Brother cartridges. Before buying either model, check the width, material, color, and replacement availability for the jobs you expect to repeat.
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PT-D220 is stronger when labels become a repeatable system
Brother gives the PT-D220 14 fonts, 11 font styles, 99 frames, 650 symbols, and 25 preset templates. More important for recurring work, it can store up to 30 labels. A small office can keep a standard file-folder pattern, a cable label, and a supply-bin format ready instead of rebuilding each one. Auto numbering, up to nine print copies, and two-line printing also help when a batch needs consistent structure.
That depth is the first reason to choose Brother. The second is tape flexibility: the 3.5 mm option reaches narrower items than DYMO's 6 mm minimum, while the specialized TZe families give one machine more surface-specific choices. The tradeoff is a desktop-style body and a menu with more options. Its one-line, 15-character graphical display is not backlit, so editing a long label is still a small-screen task rather than visual desktop publishing.
DYMO's QWERTY layout places dedicated keys for font size, bold, italic, boxes, underlining, and vertical text near the typing area. Six font sizes are available, with the actual choices depending on tape width, and the graphical LCD shows most formatting before printing. For someone making a few drawer, folder, or shelf labels at the point of use, that direct path is a genuine buying benefit.
The second benefit is portability. DYMO positions the 160 as compact and lightweight, so it is easier to carry between a closet, desk, and supply room. It also remembers the current label text and formatting after its two-minute automatic shutoff. That is convenient for several identical labels, but it is not a saved-design library: removing all power loses the current label, and switching among multiple recurring formats requires editing it. Choose the 160 when quick local edits matter more than retaining a catalog of designs.
Power and consumables decide the ownership experience
Both machines run on six AAA batteries and can use an optional AC adapter. The selected packages do not include the batteries or adapter, so either purchase needs a power plan. Brother includes a short 12 mm black-on-white laminated TZe sample; the selected DYMO machine-only package includes a black-on-white 12 mm D1 starter cassette. After those starter supplies, the cost and availability of the correct cartridge family matter more than small differences in the machine price.
Buy the PT-D220 when several people will reuse named formats, when 3.5 mm tape or specialized TZe materials solve real jobs, or when 30 saved labels and batch features will reduce repeated setup. Buy the LabelManager 160 when labels are short and occasional, the machine will travel to the storage area, and direct formatting plus D1 tape is enough. Skip both for shipping labels, wide storage signs, spreadsheet-driven batches, or app-designed graphics; those jobs call for a different class of label printer.
THE CHOICES
Which one fits your job?
01Brother P-touch PT-D220 — White / Home & Office Everyday Label Maker
WHY CONSIDER IT
Thirty saved labels, templates, auto numbering, and repeat copies reduce setup when a household or small office reuses several standard formats.
TZe widths from 3.5 to 12 mm and multiple material families cover narrower items and more surface-specific jobs than the selected DYMO system.
THE LIMITS
Its one-line 15-character display is not backlit.
Brother classifies it as a desktop model rather than a portable model.
Six AAA batteries and the optional AC adapter are not included.
TZe cartridges are an ongoing cost and do not fit DYMO machines.
02DYMO LabelManager 160 — LabelManager 160 / black / model 1790415 / QWERTY as titled and manufacturer documented / Machine Only / Single Pack / one black-on-white 1/2 inch x 10 ft starter cassette
WHY CONSIDER IT
Dedicated formatting keys and a graphical preview keep short drawer, folder, and shelf labels quick to edit at the point of use.
The compact, lightweight positioning makes it easier to carry between storage areas than a desktop-positioned label maker.
THE LIMITS
Its D1 tape range starts at 6 mm rather than 3.5 mm.
It retains one current label rather than a library of multiple saved designs.
Six AAA batteries and the optional adapter are separate purchases.
D1 cartridges are an ongoing cost and do not fit Brother machines.
Buy the products in this article
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Brother P-touch PT-D220 — White / Home & Office Everyday Label Maker
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DYMO LabelManager 160 — LabelManager 160 / black / model 1790415 / QWERTY as titled and manufacturer documented / Machine Only / Single Pack / one black-on-white 1/2 inch x 10 ft starter cassette
[4]DYMO — LabelManager 160 official user guide, revision 6/20
Additional references
Brother P-touch PT-D220 — White / Home & Office Everyday Label Maker — product details
Brother P-touch PT-D220 — White / Home & Office Everyday Label Maker — supporting source
DYMO LabelManager 160 — LabelManager 160 / black / model 1790415 / QWERTY as titled and manufacturer documented / Machine Only / Single Pack / one black-on-white 1/2 inch x 10 ft starter cassette — product details